Toxic Effects of Trazodone on Male Reproductive System via Disrupting Hypothalamic-Pituitary-Testicular Axis and Inducing Testicular Oxidative Stress
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چکیده
منابع مشابه
Diabetes Mellitus and Impairment of Male Reproductive Function: Role of Hypothalamus Pituitary Testicular Axis and Reactive Oxygen Species
Abstract Diabetes mellitus (DM) is one of the greatest public health threats in modern societies. Although during a few years it was suggested that DM had no significant effect in male reproductive function, this view has been challenged in recent years. From a clinical perspective, the evaluation of semen parameters, as well as spermatozoa deoxyribonucleic acid (DNA) integrity, are often st...
متن کاملdiabetes mellitus and impairment of male reproductive function: role of hypothalamus pituitary testicular axis and reactive oxygen species
abstract diabetes mellitus (dm) is one of the greatest public health threats in modern societies. although during a few years it was suggested that dm had no significant effect in male reproductive function, this view has been challenged in recent years. from a clinical perspective, the evaluation of semen parameters, as well as spermatozoa deoxyribonucleic acid (dna) integrity, are often studi...
متن کاملP-44: Effects of Nano Zinc Oxide Supplementation on Testicular Oxidative Stress in Adult Male Rats Exposed to Endurance Exercise
Background: Physical activity has a range of effects on male reproductive function depending upon the intensity and duration of the activity. Materials and Methods: In order to investigate the protective effects of nano zinc oxide on endurance exercise induced testicular oxidative stress, 30 adult male Wistar rats were randomly divided into the following groups: control group (n=10); exercised ...
متن کاملPituitary-testicular responsiveness in male hypogonadotropic hypogonadism.
An isolated deficiency of pituitary gonadotropins was demonstrated in six 46 XY males, 22 to 36 years of age, with and without anosmia. Undetectable or low levels of serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) clearly separated hypogonadotropic from normal adult males. Chronic (8-12 wk) administration of clomiphene citrate caused no increase in serum FSH or LH in gonad...
متن کاملEffects of LPS injection on the hypothalamic and testicular mRNA expression levels of reproductive factors in male rats.
OBJECTIVES In the hypothalamus, kisspeptin and RFamide-related peptide (RFRP) regulate gonadotropin-releasing hormone expression. Kisspeptin and RFRP are also found in the testes and might play roles in steroidogenesis and spermatogenesis. DESIGN AND RESULTS The present study demonstrated that the hypothalamic mRNA expression level of the kisspeptin receptor was decreased by the injection of ...
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ژورنال
عنوان ژورنال: Oxidative Medicine and Cellular Longevity
سال: 2018
ISSN: 1942-0900,1942-0994
DOI: 10.1155/2018/7196142